Maqashalala was born in KwaBhaca, Eastern Cape. Her break-out role was as Viwe in the first three seasons of youth drama series Tsha Tsha from 2003 to 2005. She also appeared in the SABC 1 shows Generations, Binnelanders, Dream World and Intersexions, the SABC 2 show Gauteng Maboneng, and e.tv's Rhythm City, Easy Money, Mzansi Love and The Kingdom - uKhakhayi. She also starred in the SABC 1 legal drama Diamond City in 2018 and was credited as an executive producer on the show. Diamond City later also aired on Netflix.